Akukho ukwelashwa kwesifo i-Alzheimer's, kodwa ososayensi bahlola njalo izindlela zokwelapha izimpawu zalesi sifo.
Abacwaningi basebenza nasekutholeni kusenesikhathi isifo sokulahlekelwa yingqondo esihambisana nesifo i-Alzheimer's, njengoba ukutholakala kusenesikhathi kungasiza ekwelapheni.
Ucwaningo olusha olushicilelwe ku-Frontiers in Aging Neuroscience lusikisela ukuthi i-uroformic acid ingaba yi-biomarker engaba khona yokuxilongwa kwesifo se-Alzheimer's kusenesikhathi.
I-US Centers for Disease Control and Prevention (CDC) ichaza i-dementia ngokuthi “ukukhubazeka kwenkumbulo, ukucabanga, noma ukwenza izinqumo okuphazamisa imisebenzi yansuku zonke.”
Ngaphezu kwesifo i-Alzheimer's, kunezinye izinhlobo ze-dementia ezifana ne-dementia enemizimba ye-Lewy kanye ne-vascular dementia. Kodwa i-Alzheimer's iyindlela evame kakhulu ye-dementia.
Ngokusho kombiko we-Alzheimer's Disease Association ka-2022, cishe abantu abayizigidi ezingu-6.5 e-United States baphila nalesi sifo. Ngaphezu kwalokho, abacwaningi balindele ukuthi lelo nani liphindeke kabili ngo-2050.
Ngaphezu kwalokho, abantu abanesifo i-Alzheimer's esithuthukile bangase babe nobunzima bokugwinya, ukukhuluma nokuhamba.
Kuze kube sekuqaleni kweminyaka yama-2000, ukuhlolwa kwesidumbu kwakuyiyona ndlela kuphela yokuqinisekisa ukuthi umuntu unesifo i-Alzheimer's noma olunye uhlobo lwe-dementia.
Ngokusho kweNational Institute on Aging, odokotela manje sebengenza ukubhoboza i-lumbar, okwaziwa nangokuthi ukubhoboza i-lumbar, ukuze bahlole ama-biomarker ahlobene nesifo i-Alzheimer's.
Odokotela bafuna ama-biomarker afana ne-beta-amyloid 42 (ingxenye eyinhloko yama-amyloid plaque ebuchosheni) futhi bangase babheke ukukhubazeka ku-PET scan.
“Amasu amasha okuthwebula izithombe, ikakhulukazi i-amyloid imaging, i-PET amyloid imaging, kanye ne-tau PET imaging, kusenza sibone ukukhubazeka ebuchosheni ngenkathi umuntu esaphila,” kusho uprofesa kanye nodokotela wezeMpilo Yomphakathi waseMichigan uKenneth M., uDkt. Langa. Ku-Ann Arbor, owayengahilelekile ocwaningweni, uphawule nge-podcast yakamuva ye-Michigan Medicine.
Kunezindlela eziningana zokwelapha ezitholakalayo ukusiza ukunciphisa ubukhulu bezimpawu ze-asthma futhi zinciphise ukuqhubeka kwesifo, yize zingenakuselapha.
Isibonelo, udokotela angase anikeze imithi efana ne-donepezil noma i-galantamine ukunciphisa izimpawu ze-asthma. Umuthi ocwaningwayo obizwa ngokuthi i-lecanemab ungase futhi unciphise ukuqhubeka kwesifo i-Alzheimer's.
Ngenxa yokuthi ukuhlolwa kwesifo i-Alzheimer kuyabiza futhi kungase kungabi khona kuwo wonke umuntu, abanye abacwaningi babeka phambili ukuhlolwa kusenesikhathi.
Abacwaningi baseShanghai Jiao Tong University kanye neWuxi Institute of Diagnostic Innovation eShayina bahlaziye ngokubambisana indima ye-formic acid njenge-biomarker yesifo i-Alzheimer's emchameni.
Ososayensi bakhethe le nhlanganisela ethile ngokusekelwe ocwaningweni lwabo lwangaphambilini mayelana nezimpawu zesifo i-Alzheimer's. Bakhomba ukuthi i-formaldehyde metabolism engavamile iyisici esibalulekile sokukhubazeka kwengqondo okuhlobene nokuguga.
Kulolu cwaningo, ababhali baqashe abahlanganyeli abangu-574 abavela eMemory Clinic yeSibhedlela Sixth People's Hospital eShanghai, eShayina.
Bahlukanise abahlanganyeli ngamaqembu amahlanu ngokusekelwe ekusebenzeni kwabo ekuhlolweni kokusebenza kwengqondo; la maqembu ayesukela ekuqondeni okunempilo kuya ku-Alzheimer's:
Abacwaningi baqoqe amasampula omchamo kubahlanganyeli ukuze bathole amazinga e-formic acid kanye namasampula egazi ukuze kuhlaziywe i-DNA.
Ngokuqhathanisa amazinga e-formic acid eqenjini ngalinye, abacwaningi bafunde ukuthi kwakukhona umehluko phakathi kwabahlanganyeli abanempilo engqondweni nalabo ababenokukhubazeka okuncane.
Iqembu elalinokwehla kwezinga elithile kwengqondo lalinamazinga aphezulu e-formic acid emchameni kuneqembu elaliphilile engqondweni.
Ngaphezu kwalokho, ababambiqhaza abanesifo i-Alzheimer babenamazinga aphezulu kakhulu e-formic acid emchameni wabo kunababambiqhaza abaphilile engqondweni.
Ososayensi bathole nokuthi amazinga e-urinary formic acid ahlobene ngokuphambene nokuhlolwa kwengqondo ekukhumbuleni nasekunakeni.
“Amazinga e-asidi ye-formic yomchamo akhushulwe kakhulu eqenjini lokuxilonga [ukwehla kwengqondo okubangelwa ukwehla kwengqondo], okusho ukuthi i-asidi ye-formic yomchamo ingasetshenziswa ekuxilongweni kwasekuqaleni [kwesifo i-Alzheimer's],” kubhala abalobi.
Imiphumela yalolu cwaningo ibalulekile ngezizathu eziningana, ikakhulukazi izindleko eziphezulu zokuxilonga isifo i-Alzheimer's.
Uma ucwaningo olwengeziwe lubonisa ukuthi i-uric acid ingabona ukwehla kwengqondo, lokhu kungaba ukuhlolwa okulula ukukusebenzisa nokungabizi.
Ngaphezu kwalokho, uma ukuhlolwa okunjalo kungabona ukwehla kwengqondo okuhlobene nesifo i-Alzheimer's, ochwepheshe bezempilo bangangenelela ngokushesha.
UDkt. Sandra Petersen, i-DNP, iphini likamongameli omkhulu wezempilo kanye nokuphila kahle ePegasus Senior Living, ukhulume ngalolu cwaningo engxoxweni ne-Medical News Today:
"Izinguquko kwisifo i-Alzheimer's ziqala eminyakeni engaba ngu-20 kuya kwengu-30 ngaphambi kokuxilongwa futhi zivame ukunganakwa kuze kube yilapho kwenzeka umonakalo omkhulu. Siyazi ukuthi ukutholwa kusenesikhathi kunganikeza iziguli izinketho eziningi zokwelashwa kanye nekhono lokuhlela ukunakekelwa kwesikhathi esizayo."
"Intuthuko kulolu vivinyo (olungangenisi ubhubhane futhi olungabizi) olutholakala emphakathini jikelele luzoba ushintsho olukhulu ekulweni nesifo i-Alzheimer's," kusho uDkt. Peterson.
Ososayensi basanda kuthola i-biomarker engasiza odokotela ukuthi baxilonge i-Alzheimer's esigabeni sokuqala. Lokhu kuzovumela odokotela…
Imiphumela yocwaningo olusha kumagundane ingasiza ngolunye usuku ekudaleni ukuhlolwa kwegazi okuzoba yingxenye yokuhlolwa okuvamile kwe-Alzheimer's nezinye izinhlobo ze-...
Ucwaningo olusha lusebenzisa ama-PET brain scan ukubikezela ukwehla kwengqondo ngokusekelwe ekubeni khona kwamaprotheni e-amyloid kanye ne-tau ebuchosheni, ngaphandle kwalokho ingqondo…
Odokotela okwamanje basebenzisa izivivinyo ezahlukene zokuqonda kanye nokuskena ukuze bathole isifo i-Alzheimer's. Abacwaningi bathuthukise i-algorithm engasetshenziswa kumuntu oyedwa…
Ukuhlolwa kwamehlo okusheshayo kungase ngelinye ilanga kunikeze ulwazi olubalulekile mayelana nempilo yobuchopho. Ikakhulukazi, kungabona izimpawu ze-dementia.