Akukho ukwelashwa kwesifo i-Alzheimer's, kodwa ososayensi bahlola njalo izindlela zokwelapha izimpawu zalesi sifo.
Abacwaningi basebenza nasekutholeni kusenesikhathi isifo sokulahlekelwa yingqondo esihambisana nesifo i-Alzheimer's, njengoba ukutholakala kusenesikhathi kungasiza ekwelapheni.
I-asidi ye-formic emchameni ingaba yi-biomarker engaba khona yokuxilongwa kwesifo se-Alzheimer's kusenesikhathi, ngokusho kocwaningo olusha olushicilelwe ku-Frontiers in Aging Neuroscience.
I-US Centers for Disease Control and Prevention (CDC) ichaza i-dementia ngokuthi “ukukhubazeka kwenkumbulo, ukucabanga, noma ukwenza izinqumo okuphazamisa imisebenzi yansuku zonke.”
Ngaphezu kwesifo i-Alzheimer's, kunezinye izinhlobo ze-dementia ezifana ne-dementia enemizimba ye-Lewy kanye ne-vascular dementia. Kodwa i-Alzheimer's iyindlela evame kakhulu ye-dementia.
Ngokusho kombiko we-Alzheimer's Disease Association ka-2022, cishe abantu abayizigidi ezingu-6.5 e-United States baphila nalesi sifo. Ngaphezu kwalokho, abacwaningi balindele ukuthi lelo nani liphindeke kabili ngo-2050.
Ngaphezu kwalokho, abantu abanesifo i-Alzheimer's esithuthukile bangase babe nobunzima bokugwinya, ukukhuluma nokuhamba.
Kuze kube sekuqaleni kweminyaka yama-2000, ukuhlolwa kwesidumbu kwakuyiyona ndlela kuphela yokuqinisekisa ukuthi umuntu unesifo i-Alzheimer's noma olunye uhlobo lwe-dementia.
Ngokusho kweNational Institute on Aging, odokotela manje sebengenza ukubhoboza i-lumbar, okwaziwa nangokuthi ukubhoboza i-lumbar, ukuze bahlole ama-biomarker ahlobene nesifo i-Alzheimer's.
Odokotela bafuna ama-biomarker afana ne-beta-amyloid 42, ingxenye eyinhloko yama-amyloid plaque ebuchosheni, futhi bangase babheke ukukhubazeka ku-PET scan.
“Amasu amasha okuthwebula izithombe, ikakhulukazi i-amyloid imaging, i-amyloid PET imaging, kanye ne-tau PET imaging, kusenza sibone ukukhubazeka ebuchosheni ngesikhathi umuntu esaphila,” kusho uprofesa wezempilo wase-University of Michigan nodokotela uKenneth M. Dr. Langa. e-Ann Arbor, owayengahilelekile ocwaningweni, uphawule nge-podcast yakamuva ye-Michigan Medicine.
Ezinye izindlela zokwelapha zingasiza ekunciphiseni ubukhali bezimpawu ze-asthma futhi zinciphise ukuqhubeka kwesifo, yize zingenakuselapha.
Isibonelo, udokotela angase anikeze imithi efana ne-donepezil noma i-galantamine ukunciphisa izimpawu ze-asthma. Umuthi ocwaningwayo obizwa ngokuthi i-lecanemab ungase futhi unciphise ukuqhubeka kwesifo i-Alzheimer's.
Ngenxa yokuthi ukuhlolwa kwesifo i-Alzheimer kuyabiza futhi kungase kungabi khona kuwo wonke umuntu, abanye abacwaningi babeka phambili ukuhlolwa kusenesikhathi.
Abacwaningi baseShanghai Jiaotong University kanye neWuXi Institute of Diagnostic Innovation of China bahlaziye ngokubambisana indima ye-formic acid njengesibonakaliso sesifo i-Alzheimer's emchameni.
Ososayensi bakhethe le nhlanganisela ethile ngokusekelwe ezifundweni zangaphambilini ze-biomarker yesifo i-Alzheimer's. Baphawula ukuthi i-metabolism engavamile ye-formaldehyde iyisici esibalulekile sokukhubazeka kwengqondo okuhlobene nokuguga.
Kulolu cwaningo, ababhali baqashe abahlanganyeli abangu-574 abavela eMemory Clinic yeSibhedlela Sixth People's Hospital eShanghai, eShayina.
Bahlukanise abahlanganyeli ngamaqembu amahlanu ngokusekelwe endleleni abasebenze ngayo ekuhlolweni kokusebenza kwengqondo; la maqembu asukela ekuqondeni okunempilo kuya esifweni i-Alzheimer's:
Abacwaningi baqoqe amasampula omchamo kubahlanganyeli ukuze bathole amazinga e-formic acid kanye namasampula egazi ukuze kuhlaziywe i-DNA.
Ngokuqhathanisa amazinga e-formic acid eqenjini ngalinye, abacwaningi bathole umehluko phakathi kwabahlanganyeli abanempilo engqondweni nalabo abanokukhubazeka kwengqondo okungenani ngezinga elithile.
Emaqenjini anokwehla kwezinga elithile kwengqondo, izinga le-formic acid emchameni laliphezulu kunasemaqenjini anemisebenzi yokuqonda enempilo.
Ngaphezu kwalokho, ababambiqhaza abanesifo i-Alzheimer babenamazinga aphezulu kakhulu e-formic acid emchameni wabo kunababambiqhaza abaphilile engqondweni.
Ososayensi bathole nobudlelwano obubi phakathi kwezinga le-formic acid emchameni kanye nokuhlolwa kwengqondo ezindaweni zenkumbulo nokunaka.
“I-UA yayiphakeme kakhulu eqenjini lokuxilonga [ukwehla kwengqondo okubangelwa yizinto ezithile], okusho ukuthi i-UA ingasetshenziswa ekuxilongweni kwasekuqaleni [kwesifo i-Alzheimer's],” kubhala abalobi.
Imiphumela yalolu cwaningo ibalulekile ngezizathu eziningana, ikakhulukazi izindleko eziphezulu zokuxilonga isifo i-Alzheimer's.
Uma ucwaningo olwengeziwe lubonisa ukuthi i-formate yomchamo ingabona ukwehla kwengqondo, lokhu kungaba ukuhlolwa okulula ukukusebenzisa nokungabizi.
Ngaphezu kwalokho, uma ukuhlolwa okunjalo kungabona ukwehla kwengqondo okuhlobene nesifo i-Alzheimer's, ochwepheshe bezempilo bangangenelela ngokushesha.
UDkt. Sandra Petersen, i-DNP, iphini likamongameli omkhulu wezempilo kanye nokuphila kahle ePegasus Senior Living, utshele i-Medical News Today ngalolu cwaningo:
"Izinguquko kwisifo i-Alzheimer's ziqala eminyakeni engaba ngu-20 kuya kwengu-30 ngaphambi kokuxilongwa futhi zivame ukunganakwa kuze kube yilapho kuvela umonakalo omkhulu. Siyazi ukuthi ukutholwa kusenesikhathi kungaholela ezindleleni eziningi zokwelapha iziguli kanye nekhono lokuhlela ukunakekelwa kwesikhathi esizayo."
"Impumelelo ekuhlolweni okunjalo (okungangenisi ubhubhane futhi okungabizi) okutholakala emphakathini jikelele kungaba yinto eshintsha kakhulu ekulweni nesifo i-Alzheimer's," kusho uDkt. Peterson.
Ososayensi basanda kuthola i-biomarker engasiza odokotela ukuxilonga isifo i-Alzheimer's kusenesikhathi. Lokhu kuzovumela odokotela…
Okutholakele okusha kumagundane kungasiza ngolunye usuku ekudaleni ukuhlolwa kwegazi okuzoba yingxenye yokuhlolwa okuvamile kwe-Alzheimer's nezinye izinhlobo ze-...
Ucwaningo olusha lusebenzisa ama-PET brain scan ukubikezela ukwehla kwengqondo ngokusekelwe ekubeni khona kwamaprotheni e-amyloid kanye ne-tau ebuchosheni, phakathi kwezinye izinto zobuchopho…
Odokotela okwamanje basebenzisa izivivinyo ezahlukene zokuqonda kanye nokuskena ukuze bathole isifo i-Alzheimer's. Abacwaningi bathuthukise i-algorithm engasetshenziswa kumuntu oyedwa…
Ukuhlolwa kwamehlo okusheshayo kungase ngelinye ilanga kunikeze ulwazi olubalulekile mayelana nempilo yobuchopho. Ikakhulukazi, kungabona izimpawu ze-dementia.