I-NICE isincome okokuqala ukwelashwa okusha okungasiza izinsana, izingane kanye nentsha ethola ukwelashwa komdlavuza ukuthi igweme ukulahlekelwa ukuzwa.
I-Cisplatin umuthi onamandla we-chemotherapy osetshenziswa kabanzi ukwelapha izinhlobo eziningi zomdlavuza wezingane. Ngokuhamba kwesikhathi, i-cisplatin inganqwabelana endlebeni yangaphakathi futhi ibangele ukuvuvukala kanye nomonakalo owaziwa ngokuthi yi-ototoxicity, okuyimbangela eyodwa yokulahlekelwa ukuzwa.
Izincomo zokugcina ezibhalwe phansi zincoma ukusetshenziswa kwe-anhydrous sodium thiosulfate, eyaziwa nangokuthi i-Pedmarqsi futhi ekhiqizwa yi-Norgine, ukuvimbela ukulahlekelwa ukuzwa okubangelwa yi-cisplatin chemotherapy ezinganeni ezineminyaka ephakathi kwenyanga eyodwa kuya kwengu-17 ubudala ezinezimila eziqinile ezingakasabalali kwezinye izingxenye zomzimba.
Cishe ama-60% ezingane ezelashwa nge-cisplatin zizoba nokulahlekelwa ukuzwa unomphela, kanti amacala amasha angu-283 okulahlekelwa ukuzwa ngenxa ye-ototoxic atholakale ezinganeni ezingaphansi kweminyaka engu-18 ubudala eNgilandi phakathi kuka-2022 no-2023.
Umuthi, onikezwa njengomjovo ngumhlengikazi noma udokotela, usebenza ngokubopha i-cisplatin engakathathwa ngamaseli futhi uvimbele ukusebenza kwayo, ngaleyo ndlela uvimbele ukulimala kwamaseli endlebe. Ukusetshenziswa kwe-sodium thiosulfate anhydrous akuthinti ukusebenza kahle kwe-cisplatin chemotherapy.
Kulinganiselwa ukuthi ngonyaka wokuqala wokunconywa kokusetshenziswa kwe-sodium thiosulfate engamanzi, cishe izingane eziyizigidi ezingu-60 kanye nentsha eNgilandi zizofanelekela ukuthola lo muthi.
Ukulahlekelwa ukuzwa ngenxa yokwelashwa komdlavuza kungaba nomthelela omubi kakhulu ezinganeni nasemindenini yazo, ngakho-ke siyajabula ukukwazi ukuncoma lolu khetho lokwelashwa olusha.
Lona umuthi wokuqala ofakazelwe ukuthi uvimbela futhi unciphisa imiphumela yokulahlekelwa ukuzwa futhi uzoba nomthelela omkhulu empilweni yezingane nentsha.
UHelen uqhube wathi: “Isincomo sethu salolu hlobo lokwelashwa olusha sibonisa ukuzibophezela kwe-NICE ekugxileni kulokho okubaluleke kakhulu: ukunikeza iziguli ukunakekelwa okungcono kakhulu ngokushesha nokuqinisekisa inani elihle lemali yomkhokhi wentela.”
Idatha evela ezivivinyweni ezimbili zezokwelapha ibonise ukuthi ukwelashwa kunciphise cishe ngesigamu izinga lokulahlekelwa ukuzwa ezinganeni ezithole i-cisplatin chemotherapy. Olunye ucwaningo lwezokwelapha luthole ukuthi izingane ezithole i-cisplatin chemotherapy elandelwa yi-anhydrous sodium thiosulfate zazinezinga lokulahlekelwa ukuzwa elingu-32.7%, uma kuqhathaniswa nezinga lokulahlekelwa ukuzwa elingu-63% ezinganeni ezithole i-cisplatin chemotherapy kuphela.
Kolunye ucwaningo, ama-56.4% ezingane ezithola i-cisplatin yodwa alahlekelwe ukuzwa, uma kuqhathaniswa nama-28.6% ezingane ezithola i-cisplatin kulandele i-anhydrous sodium thiosulfate.
Ukuhlolwa kuphinde kwabonisa ukuthi uma izingane ziqala ukulahlekelwa ukuzwa, ngokuvamile kwakungekubi kangako kulabo abasebenzisa i-sodium thiosulfate engamanzi.
Abazali batshele ikomidi elizimele le-NICE ukuthi uma ukulahlekelwa ukuzwa kwenzeka ngenxa ye-cisplatin chemotherapy, kungathinta ukuthuthukiswa kwenkulumo nolimi, kanye nokusebenza esikoleni nasekhaya.
Siyajabula ukumemezela ukuthi lo muthi oyinhloko uzosetshenziswa ezigulini ezisencane ezithola ukwelashwa komdlavuza ukuvimbela ukulahlekelwa ukuzwa njengomphumela ongemuhle we-cisplatin chemotherapy.
URalph uqhube wathi: “Silangazelela ukubona lo muthi ezibhedlela kulo lonke izwe futhi sinethemba lokuthi bonke abantwana abangazuza kuwo maduze bazothola lo muthi osindisa impilo. Siyabonga kubasekeli bethu ngegalelo labo, eliye lenza i-RNID yakwazi ukunikeza i-NICE imibono ebalulekile nobufakazi bokusiza ukwenza lo muthi utholakale kabanzi kulo lonke elase-UK. Lesi yisikhathi sokuqala ukuthi umuthi uthuthukiswe ngqo ukuvimbela ukulahlekelwa ukuzwa futhi unconywa ukuthi usetshenziswe kwi-NHS. Lesi yisinyathelo esibalulekile esizonikeza labo abatshala imali futhi bathuthukise ukwelashwa kokulahlekelwa ukuzwa ukuzethemba kokuthi bangawuletha ngempumelelo umuthi emakethe.”
Ukwelashwa kuzotholakala kwi-NHS eNgilandi zingakapheli izinyanga ezintathu kusukela kushicilelwe isiqondiso sokugcina se-NICE.
Le nkampani ingene esivumelwaneni sezentengiselwano esiyimfihlo sokuhlinzeka nge-sodium thiosulfate engamanzi kwiNational Health Service ngentengo ephansi.