Sisebenzisa amakhukhi ukuthuthukisa ulwazi lwakho. Ngokuqhubeka uphequlula le sayithi, uyavuma ukusebenzisa kwethu amakhukhi. Ulwazi olwengeziwe.
Ngokuchofoza okuthi “Vumela Konke”, uyavuma ukuthi amakhukhi agcinwe kudivayisi yakho ukuze kuthuthukiswe ukuzulazula kwesayithi, kuhlaziywe ukusetshenziswa kwesayithi, futhi kusekelwe ekuhlinzekweni kwethu kokuqukethwe kwesayensi kwamahhala, okufinyelela kalula. Ulwazi olwengeziwe.
Ingabe ukuhlolwa komchamo okulula kungathola isifo i-Alzheimer's esisesigabeni sokuqala, okuvule indlela yezinhlelo zokuhlola ngobuningi? Ucwaningo olusha lwe-Frontiers in Aging Neuroscience lukhombisa lokhu ngokuqinisekile. Abacwaningi bahlole iqembu elikhulu leziguli ze-Alzheimer's ezinobunzima obuhlukahlukene kanye nabantu abaphilile ababejwayelekile ngokwengqondo ukuze bathole umehluko kuma-biomarker omchamo.
Bathole ukuthi i-formic acid emchameni iyisibonakaliso esibucayi sokwehla kwengqondo okubonakalayo futhi ingase ibonise izigaba zokuqala zesifo i-Alzheimer's. Izindlela ezikhona zokuxilonga isifo i-Alzheimer's ziyabiza, azilungele ukuhlolwa njalo. Lokhu kusho ukuthi iziguli eziningi zixilongwa kuphela uma sekwephuze kakhulu ukwelashwa okuphumelelayo. Kodwa-ke, ukuhlolwa komchamo okungangenisi, okungabizi, nokulula kwe-formic acid kungaba yilokho kanye odokotela abakucelayo ukuze kuhlolwe kusenesikhathi.
“Isifo i-Alzheimer’s siyisifo esingamahlalakhona esiqhubekayo nesicashile, okusho ukuthi singakhula futhi siqhubeke iminyaka eminingi ngaphambi kokuba kuvele ukuphazamiseka okusobala kokuqonda,” kusho abalobi. “Izigaba zokuqala zalesi sifo zenzeka ngaphambi kwesigaba se-dementia engenakuguqulwa, okuyifasitela legolide lokungenelela nokwelashwa. Ngakho-ke, ukuhlolwa okukhulu kwesifo i-Alzheimer’s esiteji sokuqala kubantu asebekhulile kuyadingeka.”
Ngakho-ke, uma ukungenelela kusenesikhathi kubalulekile, kungani singenazo izinhlelo zokuhlola isifo se-Alzheimer's esisesigabeni sokuqala? Inkinga isezindleleni zokuxilonga odokotela abazisebenzisayo njengamanje. Lokhu kufaka phakathi i-positron emission tomography yobuchopho, ebiza kakhulu futhi eveza iziguli emisebeni. Kukhona nokuhlolwa kwe-biomarker okungathola i-Alzheimer's, kodwa kudinga ukukhishwa kwegazi okungenayo noma ukubhobozwa kwe-lumbar ukuze kutholakale uketshezi lwe-cerebrospinal, okungenzeka ukuthi iziguli ziyakuhlehlisa.
Kodwa-ke, ukuhlolwa komchamo akuhlaseli futhi kulula, okwenza kube kuhle kakhulu ekuhlolweni kwabantu abaningi. Nakuba abacwaningi sebethole ama-biomarker omchamo wesifo i-Alzheimer's, awekho afanele ukuthola izigaba zokuqala zalesi sifo, okusho ukuthi ithuba lokwelashwa kwasekuqaleni lisalokhu lingekho.
Abacwaningi abasungula lolu cwaningo olusha bake bafunda ngaphambilini nge-organic compound ebizwa ngokuthi i-formaldehyde njenge-biomarker yomchamo yesifo i-Alzheimer's. Kodwa-ke, kunethuba lokuthuthuka ekutholakaleni kwesifo kusenesikhathi. Kulolu cwaningo lwakamuva, bagxile ku-formate, i-metabolite ye-formaldehyde, ukuze babone ukuthi isebenza kangcono yini njenge-biomarker.
Abantu abangu-574 bahlanganyele ocwaningweni, kanti ababambiqhaza babengabavolontiya abaphilile ngokwengqondo noma babenezinga elihlukahlukene lokuqhubeka kwesifo, kusukela ekuwohlokeni kwengqondo okubonakalayo kuye ekuguleni okuphelele. Abacwaningi bahlaziye amasampula omchamo negazi avela kubabambiqhaza futhi benza ukuhlolwa kwengqondo.
Ucwaningo luthole ukuthi amazinga e-acid ye-urinary formic acid ayephakeme kakhulu kuwo wonke amaqembu esifo se-Alzheimer futhi ahlobene nokwehla kwengqondo uma kuqhathaniswa nezilawuli ezinempilo, kufaka phakathi iqembu lokuqala lokwehla kwengqondo elizimele. Lokhu kusikisela ukuthi i-acid ye-formic ingasebenza njenge-biomarker ebucayi yezigaba zokuqala zesifo se-Alzheimer.
Ngokuthakazelisayo, lapho abacwaningi behlaziya amazinga e-urine formate kanye nama-biomarker egazi le-Alzheimer's, bathole ukuthi bangabikezela ngokunembile isigaba sesifo isiguli esidlula kuso. Kodwa-ke, kudingeka ucwaningo olwengeziwe ukuze kuqondwe ukuxhumana phakathi kwesifo se-Alzheimer's kanye ne-formic acid.
“I-asidi ye-Urine formic ibonise ukuzwela okuhle kakhulu ekuhlolweni kwasekuqaleni kwesifo i-Alzheimer’s,” kusho abalobi. “Ukuhlolwa kwe-biomarker yomchamo yesifo i-Alzheimer’s kulula futhi kuyabiza futhi kufanele kufakwe ekuhlolweni kwezempilo okuvamile kwabantu asebekhulile.”
UWang, Y. et al. (2022) Ukubuyekezwa okuhlelekile kwe-urinary formic acid njenge-biomarker entsha engaba khona yesifo i-Alzheimer's. Imingcele ku-neurobiology yokuguga. doi.org/10.3389/fnagi.2022.1046066.
Amathegi: ukuguga, isifo sika-Alzheimer, ama-biomarker, igazi, ubuchopho, okungamahlalakhona, izifo ezingamahlalakhona, ama-compounds, i-dementia, ukuxilongwa, odokotela, i-formaldehyde, i-neurology, i-positron emission tomography, ucwaningo, i-tomography, i-urinalysis
EPittcon 2023 ePhiladelphia, ePennsylvania, sixoxe noSolwazi uJoseph Wang, owine umklomelo weRalph N. Adams ku-Analytical Chemistry walo nyaka, mayelana nokuguquguquka kobuchwepheshe be-biosensor.
Kule ngxoxo, sixoxa nge-biopsy yokuphefumula nokuthi ingaba kanjani ithuluzi eliwusizo lokufunda ama-biomarker ukuze kutholakale isifo kusenesikhathi noMariana Leal, uMholi Wethimba kwa-Owlstone Medical.
Njengengxenye yokubuyekezwa kwethu kwe-SLAS US 2023, sixoxa ngelebhu yesikhathi esizayo nokuthi ingaba njani noLuigi Da Via, uMholi weQembu Lokuthuthukiswa Kokuhlolwa kwe-GSK.
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