Umcwaningi waseFrance uphakamise ukuqwashisa ngezingozi zezinaliti ezibukhali emalabhorethri ngemuva kwengozi esabekayo ehilela ukuvuza kwe-solvent okuvamile. Manje ucela ukuthuthukiswa kwezindlela zokufaka esikhundleni sezinaliti zokudlulisa izinyibilikisi noma ama-reagent ukuze kuthuthukiswe ukuphepha kwelabhorethri. 1
NgoJuni 2018, umfundi oneminyaka engu-22 ubudala uNicolas wayesebenza elabhorethri kaSebastien Vidal eNyuvesi yaseLyon 1. Wathela isirinji se-dichloromethane (DXM) eflaskini wabe esehlaba umunwe wakhe ngephutha. UVidal wabala ukuthi cishe amaconsi amabili noma ngaphansi kwama-microliter ayi-100 e-DXM asele enalitini futhi angena emunweni.
Uchungechunge lwezithombe ezinemifanekiso lubonisa okwenzeka ngokulandelayo – isihloko sikamagazini sixwayisa ngokuthi abanye bangase bathole izithombe (ezingezansi) ziphazamisa. Cishe imizuzu eyi-15 ngemva kokuhlatshwa ngenaliti, uNicolas wakha ibala elinsomi emunweni wakhe. Ngemva kwamahora amabili, imiphetho yama-plaque ansomi yaqala ukuba mnyama, okubonisa ukuqala kwe-necrosis – ukufa kwamangqamuzana. Kuleli qophelo, uNicholas wakhononda ngokuthi iminwe yakhe yayishisa futhi wayengenakukwazi ukuyishukumisa.
UNicholas wadinga ukuhlinzwa okuphuthumayo ukuze asindise umunwe wakhe. Odokotela abahlinzayo, ababecabanga ukuthi kuzodingeka anqunywe ekuqaleni, bakwazile ukususa isikhumba esifile esizungeze inxeba lokugwazwa futhi bakha kabusha umunwe besebenzisa i-graft yesikhumba esandleni sikaNicholas. Kamuva udokotela ohlinzayo wakhumbula ukuthi eminyakeni yakhe engama-25 esebenza emakamelweni ezimo eziphuthumayo, wayengakaze abone ukulimala okunjalo.
Iminwe kaNicholas isicishe ibuyele esimweni sayo esijwayelekile, yize ukudlala kwakhe isiginci kwahlushwa yi-necrosis eyalimaza imizwa yakhe, kwanciphisa amandla akhe kanye nekhono lakhe.
I-DCM ingenye yezinyibilikisi eziphilayo ezisetshenziswa kakhulu emalabhorethri e-chemistry yokwenziwa. I-DCM Injury Information kanye ne-Material Safety Data Sheet yayo (MSDS) inikeza imininingwane ngokuxhumana kwamehlo, ukuxhumana kwesikhumba, ukugwinya kanye nokuphefumula, kodwa hhayi ngomjovo, kusho uVidal. Ngesikhathi sophenyo, uVidal uthole ukuthi isigameko esifanayo senzeke eThailand, yize le ndoda yazijova ngokuzithandela ngamamililitha ama-2 e-dichloromethane, imiphumela yayo yabikwa esibhedlela saseBangkok. 2
Lezi zimo zibonisa ukuthi amafayela e-MSDS kufanele ashintshwe ukuze afake ulwazi oluhlobene ne-parenterals, kusho uVidal. “Kodwa isikhulu sami sezokuphepha eyunivesithi singitshele ukuthi ukuguqula amafayela e-MSDS kuzothatha isikhathi eside futhi kudinga idatha eningi ukuze kuqoqwe.” Lokhu kufaka phakathi izifundo zezilwane ezinemininingwane ukuze kuphinde kukhiqizwe ingozi, ukuhlaziywa komonakalo wezicubu, kanye nokuhlolwa kwezokwelapha.
Iminwe yabafundi ngezigaba ezahlukene ngemva kokujova ngengozi inani elincane le-methylene chloride. Kusukela kwesobunxele kuya kwesokudla, imizuzu eyi-10-15 ngemva kokulimala, bese kuba amahora ama-2, amahora angama-24 (ngemuva kokuhlinzwa), izinsuku ezi-2, izinsuku ezi-5, kanye nonyaka owodwa (zombili izithombe ezingezansi)
Njengoba kungekho ulwazi mayelana nokuqaliswa kwe-DCM, uVidal unethemba lokuthi le ndaba izosakazwa kabanzi. Impendulo iyakha. Uthe lo mbhalo [usakazwe kabanzi]. "Izikhulu zokuphepha ezivela emanyuvesi aseCanada, e-US naseFrance zingitshele ukuthi zizofaka le ndaba ezinhlelweni zazo zokufunda. Abantu basibongile ngokwabelana ngale ndaba. Abaningi babengafuni ukukhuluma ngayo ngenxa yokwesaba ukudalulwa okubi [ngesikhungo sabo] Kodwa izikhungo zethu bezilokhu zisekela kakhulu kusukela ekuqaleni futhi zisasekela namanje."
UVidal ufuna futhi umphakathi wesayensi kanye nabaphakeli bamakhemikhali bathuthukise izinqubo eziphephile kanye nemishini ehlukile yezinqubo ezijwayelekile njengokudluliselwa kwamakhemikhali. Omunye umqondo ukusebenzisa inaliti “eqondile” ukugwema amanxeba okubhoboza. “Ziyatholakala manje, kodwa ngokuvamile sisebenzisa izinaliti eziqondile kumakhemikhali ezinto eziphilayo ngoba sidinga ukwethula izinyibilikisi ngokusebenzisa izithiyo zerabha ukuze sivikele imithambo yethu yokusabela emoyeni/umswakama wangaphandle. Izinaliti “eziqondile” azikwazi ukudlula ezithiyo zerabha. Lo akuwona umbuzo olula, kodwa mhlawumbe lokhu kwehluleka kuzoholela emibonweni emihle.
U-Alain Martin, umphathi wezempilo nokuphepha eMnyangweni Wekhemistri wase-University of Strathclyde, uthe akakaze ayibone ingozi enjalo. “Elabhorethri, kuvame ukusetshenziswa amasirinji anezinaliti, kodwa uma ukunemba kubalulekile, khona-ke ukusebenzisa ama-micropipettes kungaba yindlela ephephile,” uyanezela, kuye ngokuqeqeshwa, njengokukhetha amathiphu nokusebenzisa ama-pipettes ngendlela efanele. “Ingabe abafundi bethu bafundiswa ukuthi bangazisingatha kanjani kahle izinaliti, bangazifaka futhi bazisuse kanjani izinaliti?” ebuza. “Ukhona ocabanga ukuthi yini enye engasetshenziswa? Mhlawumbe cha.
2 K. Sanprasert, T. Thangrongchitr kanye no-N. Krairojananan, Asia. Pakisha. J. Med. I-Toxicology, 2018, 7, 84 (DOI: 10.22038/apjmt.2018.11981)
Umnikelo wezigidi ezingama-210 zamaRandi ovela kusomabhizinisi weModerna kanye nomtshalizimali uTim Springer ukusekela ucwaningo oluqhubekayo
Inhlanganisela yokuhlolwa kwe-X-ray diffraction kanye nokulingisa kubonisa ukuthi ukukhanya okukhulu kwe-laser kungaguqula i-polystyrene.
© Royal Society of Chemistry document.write(new Date().getFullYear()); Inombolo yokubhalisa yenhlangano yokusiza umphakathi: 207890